Melanotan 2

Description

MT-2 / Melanotan II, (CAS 121062-08-6) is a synthetic cyclic heptapeptide and non-selective pan-agonist of melanocortin receptors MC1R, MC3R, MC4R, and MC5R, developed at the University of Arizona by Hruby, Hadley, and colleagues in the 1980s–1990s as a potent, metabolically stable α-MSH analog for melanocortin receptor pharmacology research, supplied by AusPepLabs in lyophilized format for laboratory and analytical research applications. As the broadest-spectrum melanocortin receptor agonist available for laboratory research, MT-2 serves as the foundational pan-receptor reference compound for studying melanocortin receptor subtype pharmacology, structure-activity relationships, and cAMP signaling cascades across multiple receptor subtypes simultaneously in controlled experimental systems. Each vial is independently verified to ≥99% HPLC purity with a Certificate of Analysis available on request. For scientific research use only.

Why Research Laboratories Select MT-2

MT-2 is the broadest-spectrum synthetic melanocortin receptor agonist available for laboratory research – activating MC1R, MC3R, MC4R, and MC5R simultaneously with no significant MC2R activity. This pan-receptor profile makes it the foundational reference compound for comparative melanocortin receptor pharmacology studies, structure-activity relationship research, and multi-receptor signaling cascade investigations. Its cyclic heptapeptide structure confers excellent aqueous solubility and enhanced metabolic stability compared to linear α-MSH analogs, making it technically straightforward to work with across diverse assay platforms.

• Pan-melanocortin receptor agonist – activates MC1R, MC3R, MC4R, and MC5R with no significant MC2R binding
• Cyclic heptapeptide structure – excellent aqueous solubility and enhanced metabolic stability vs linear α-MSH analogs
• Foundational reference compound – used as pan-receptor reference against which selective analogs including MT-1 and PT-141 are compared
• Competitive binding assays – Ki values in sub-nanomolar to low nanomolar range at MC1R, MC3R, MC4R, MC5R
• Parent compound of PT-141 (Bremelanotide/Vyleesi) – established molecular lineage in melanocortin pharmacology research
• Studied in C57BL/6 and other rodent models for melanocortin system biology research
• Referenced in peer-reviewed literature spanning over three decades of melanocortin receptor pharmacology research