Kisspeptin-10

Description

Kisspeptin-10 (KP-10, CAS 374675-21-5) is a synthetic C-terminally amidated decapeptide representing the minimal active C-terminal sequence of the endogenous KISS1 gene product (kisspeptin-54/metastin), supplied by AusPepLabs for laboratory and analytical research applications. As the shortest kisspeptin fragment retaining full intrinsic agonist activity at the KISS1R receptor (GPR54), Kisspeptin-10 is one of the most widely used research tools in reproductive endocrinology, neuroendocrine signaling, and hypothalamic-pituitary-gonadal (HPG) axis biology. Each vial is independently verified to ≥99% HPLC purity with a Certificate of Analysis available on request. For scientific research use only.

Why Research Laboratories Select Kisspeptin-10

Kisspeptin-10 is the minimal active sequence of the kisspeptin family and the most widely used kisspeptin isoform in laboratory research. As a full agonist at KISS1R/GPR54 with potency comparable to kisspeptin-54, it enables precise investigation of GPR54-mediated signaling without the added complexity of longer kisspeptin variants. Its role as an upstream regulator of GnRH neuron activation makes it an essential reference compound for laboratories investigating HPG axis biology, reproductive neuroendocrinology, and gonadotropin secretion models.

• Minimal active kisspeptin fragment -10 amino acid C-terminal sequence retaining full GPR54 agonist activity
• KISS1R/GPR54 full agonist – activates Gq/11α signaling, calcium mobilization, and ERK1/2/p38 MAPK phosphorylation in experimental systems
• Key upstream regulator of GnRH neuron activation – studied in HPG axis, LH and FSH secretion, and reproductive neuroendocrine research models
• Originally identified as a metastasis suppressor gene product – referenced in oncology, angiogenesis inhibition, and tumor biology research
• Referenced in peer-reviewed literature including New England Journal of Medicine, Physiological Reviews, and Journal of Clinical Endocrinology & Metabolism
• Lyophilized format ensures stability and reproducibility across experimental runs